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Cellular signalling and cancer therapy - EMBO Conference May 23rd-27th 2014

Visit Léo Aubert, he will present his works on TrkA and CD44 signaling Submitted abstract

Cancéropôle Meeting - May 14-15-16th 2014

Visit Matthieu Guilbert, he will present his works on TrkA signaling Submitted abstract Nouvelle fenetre


Our publications

Role of p75 neurotrophin receptor in stem cell biology: more than just a marker. Nouvelle fenetre
Tomellini E, Lagadec C, Polakowska R, Le Bourhis X.
Cell Mol Life Sci. 2014 Jan 31.

The in vivo performance of ferrocenyl tamoxifen lipid nanocapsules in xenografted triple negative breast cancer. Nouvelle fenetre
Lainé AL, Adriaenssens E, Vessières A, Jaouen G, Corbet C, Desruelles E, Pigeon P, Toillon RA, Passirani C.
Biomaterials. 2013 Sep;34(28):6949-56. doi: 10.1016/j.biomaterials.2013.05.065.

Antiproliferative and apoptotic effects of the oxidative dimerization product of methyl caffeate on human breast cancer cells. Nouvelle fenetre
Bailly F, Toillon RA, Tomavo O, Jouy N, Hondermarck H, Cotelle P.
Bioorg Med Chem Lett. 2013 Jan 15;23(2):574-8. doi: 10.1016/j.bmcl.2012.11.009.

Pro-nerve growth factor induces autocrine stimulation of breast cancer cell invasion through tropomyosin-related kinase A (TrkA) and sortilin protein. Nouvelle fenetre
Demont Y, Corbet C, Page A, Ataman-Önal Y, Choquet-Kastylevsky G, Fliniaux I, Le Bourhis X, Toillon RA, Bradshaw RA, Hondermarck H.
J Biol Chem. 2012 Jan 13;287(3):1923-31. doi: 10.1074/jbc.M110.211714. Epub 2011 Nov 29.

Brain-derived neurotrophic factor and neurotrophin-4/5 are expressed in breast cancer and can be targeted to inhibit tumor cell survival. Nouvelle fenetre
Vanhecke E, Adriaenssens E, Verbeke S, Meignan S, Germain E, Berteaux N, Nurcombe V, Le Bourhis X, Hondermarck H.
Clin Cancer Res. 2011 Apr 1;17(7):1741-52. doi: 10.1158/1078-0432.CCR-10-1890.

Proteome changes induced by overexpression of the p75 neurotrophin receptor (p75NTR) in breast cancer cells. Nouvelle fenetre
Wilmet JP, Tastet C, Desruelles E, Ziental-Gelus N, Blanckaert V, Hondermarck H, Le Bourhis X.
Int J Dev Biol. 2011;55(7-9):801-9. doi: 10.1387/ijdb.113345jw.

Overexpression of p75(NTR) increases survival of breast cancer cells through p21(waf1). Nouvelle fenetre
Verbeke S, Meignan S, Lagadec C, Germain E, Hondermarck H, Adriaenssens E, Le Bourhis X.
Cell Signal. 2010 Dec;22(12):1864-73. doi: 10.1016/j.cellsig.2010.07.014.

Ku86 is important for TrkA overexpression-induced breast cancer cell invasion. Nouvelle fenetre
Lagadec C, Romon R, Tastet C, Meignan S, Com E, Page A, Bidaux G, Hondermarck H, Le Bourhis X.
Proteomics Clin Appl. 2010 Jul;4(6-7):580-90. doi: 10.1002/prca.200900148.

TrkA overexpression enhances growth and metastasis of breast cancer cells. Nouvelle fenetre
Lagadec C, Meignan S, Adriaenssens E, Foveau B, Vanhecke E, Romon R, Toillon RA, Oxombre B, Hondermarck H, Le Bourhis X.
Oncogene. 2009 May 7;28(18):1960-70. doi: 10.1038/onc.2009.61.